Influence of biodegradable polymer membrane on new bone formation and biodegradation of biphasic bone substitutes: an animal mandibular defect model study
구정귀, 김영균, 윤필영,
소속 상세정보
구정귀 ( Ku Jeong-Kui ) - Armed Forces Medical Command Armed Forces Capital Dental Hospital Department of Oral and Maxillofacial Surgery
김영균 ( Kim Young-Kyun ) - Seoul National University Bundang Hospital Department of Oral and Maxillofacial Surgery
윤필영 ( Yun Pil-Young ) - Seoul National University Bundang Hospital Department of Oral and Maxillofacial Surgery
Abstract
Purpose: The purpose of this study was to evaluate the influence of biodegradable polycaprolactone membrane on new bone formation and the biodegradation of biphasic alloplastic bone substitutes using animal models.
Materials and methods: In this study, bony defect was formed at the canine mandible of 8?mm in diameter, and the defects were filled with Osteon II. The experimental groups were covered with Osteoguide as barrier membrane, and the control groups were closed without membrane coverage. The proportion of new bone and residual bone graft material was measured histologically and histomorphometrically at postoperative 4 and 8?weeks.
Results: At 4?weeks, the new bone proportion was similar between the groups. The proportion of remaining graft volume was 27.58 ± 6.26 and 20.01 ± 4.68% on control and experimental groups, respectively (P < 0.05). There was no significant difference between the two groups in new bone formation and the amount of residual bone graft material at 8?weeks.
Conclusion: The biopolymer membrane contributes to early biodegradation of biphasic bone substitutes in the jaw defect but it does not affect the bone formation capacity of the bone graft.
키워드
Beta-tricalcium phosphate; Biphasic calcium phosphate; Bone regeneration; Hydroxyapatite; Membrane; Polycaprolactone
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